Tuesday, July 3, 2012

Diplomacy failing, West faces tough Syria choices

LONDON (Reuters) - There are few signs diplomacy can stem Syria's worsening conflict, leaving Western leaders - and even more so their Arab and Turkish allies - pushed ever further towards backing Bashar al-Assad's ouster by force.

In Geneva on Saturday, world powers attempted a vague show of unity by committing to support for a transitional government. But diplomats led by United Nations envoy Kofi Annan failed to bridge differences between the West and Russia - backed by China - on whether or not that meant that Syria's president must go.

In any case, neither Assad's government nor his various opponents have shown great interest in such an accord. Instead, both sides look to be digging in for a long, winner-takes-all struggle, ramping up the violence and turning to foreign sponsors in a confrontation that could last months, or years.

A meeting in Paris this coming Friday of the loose alliance known as the Friends of Syria is likely see the United States in particular come under greater pressure from Turkey and the Syrian opposition's Arab allies - principally Saudi Arabia and the Gulf state of Qatar - to increase its help for the rebels.

Washington has long worried about the wisdom of backing Syria's opposition, which it sees as ill-organized, disparate and much too close to al Qaeda-linked militants. It has limited aid to "non-lethal" equipment, such as radios. And, in an election year, the White House is anxious to avoid anything that may look like an Afghan-style, open-ended military intervention.

Yet it also acknowledges that some of its allies have opted to get more involved in actively support the rebel campaign.

"We're concerned about pouring more weapons into an already over-militarized situation," U.S. State Department spokeswoman Victoria Nuland said on Monday. "We've made our decision.

"Other countries are making other decisions. Our goal now is trying to stay coordinated."

Though public details on aid to the rebels are scant, U.S. officials say Saudi- and Qatari-funded weaponry is finding its way, mostly via Lebanon, into Syria, to be used against Assad, whose Alawite religion and alliance with Shi'ite Iran distance him from the Sunni Muslims who run most other Arab states.

Some fear foreign powers may simply be making things worse.

"The unfortunate truth is that it's a very difficult situation and it's hard to know where to go from here," said Ari Ratner, a former State Department Middle East adviser to the Obama Administration and now a fellow at the Truman Project on National Security. "Other countries are being dragged into a proxy war ... which may in itself help perpetuate the violence."

On Monday, U.N. human rights chief Navi Pillay complained both sides were receiving more and more weapons, creating more violence - though she did not say who was sending them. Assad has bought much of his weaponry from longstanding ally Russia.

The Western powers remain publicly committed to other tools to weaken Assad's grip on power - primarily financial sanctions.

U.S. officials say they hope Syria's opposition will endorse the Geneva plan for sharing power with Assad loyalists when they meet in Paris on Friday, though for now opposition spokesman have been asking instead for weapons. Washington has flatly refused, although it says it cannot stop others from offering.

Compared to Assad's forces - increasingly using not just tanks and armored vehicles but also artillery and attack helicopters - the Free Syrian Army remains desperately underequipped, capable of little more than hit and run attacks.

While they have fought on for months in pockets such as Homs, where they benefit from weapons smuggled across the border from Lebanon, they can still barely hold ground. Nor do they have many military options when government forces withdraw from opposition areas only to then pound them with artillery shells supplied from either Russia or Iran.

BUFFER ZONE

Yet for all the concern about contributing to further bloodshed, some who wish to see Assad gone see arming the rebels as a better option than simply waiting, or than any form of direct Libya-style campaign committing warplanes or even troops.

Turkish action in the past week - following the shooting down of a Turkish reconnaissance jet by Syrian air defenses - may be the clearest example yet of foreign action to redraw the lines of battle in favor of the rebels.

Last week, Turkey moved heavy artillery and anti-aircraft missiles up to its border with Syria, publicly warning Damascus that any forces which approached Turkish territory might be liable to attack.

The Assad government looks to have made occasional attempts to test Turkey's resolve, but with Ankara scrambling fighter jets several times after Syrian helicopters approached its airspace, they have begun to pull forces back.

A Reuters correspondent of the border said that it appeared Assad's ground forces had withdrawn some 30 km (20 miles) back into their own territory, although they were shelling presumed opposition areas only 8 km (5 miles) from the Turkish border.

Some opposition activists complain the Turkish action has actually made things worse, as areas once garrisoned with Syrian troops are now simply being bombarded.

Still, it has created something of a de facto buffer zone, increasing the freedom to maneuver of rebel fighters already operating from Turkey. With Syrian aircraft also likely to try to avoid attracting Turkish fire, some analysts say a de facto no-fly zone may also now effectively exist over the area.

Having sheltered leaders of the Free Syrian Army and allowed them to operate from its territory for months, Ankara now seems signaling much clearer support for the opposition.

"What we now have today is a regime who has strayed so far away from a basic sense of rationality," Turkish Foreign Minister Ahmet Davotoglu told a Syrian opposition meeting in Cairo on Monday.

"The only interlocutor for Turkey in Syria is now the Syrian people, ... that is the Syrian opposition, which means you."

That seems likely to mean that Ankara will let the Gulf Arab states increase shipments of military supplies to FSA forces based in Turkey. For the opposition, they are sorely needed.

Western intelligence and special forces operatives already believed to be operating in Turkey may also be pressured to provide much greater support. So far, officials in Washington in particular say their primary task has been less to assist the rebels and much more to find out who they are and whether it might ever be safe to work with them more closely.

GOING IN CIRCLES?

The uncertainties of taking action compare to an apparently growing certainty that diplomacy is making little progress.

"The wheels clearly are going in circles without moving forward," said Hayat Alvi, lecturer in Middle Eastern studies at the U.S. Naval War College. "The proof is the Assad regime's continuous acts of violence against the Syrian people, even while the diplomatic wheels have been turning.

"That will likely be the scenario for months to come."

Western officials also appear to be shelving ambitions of persuading Vladimir Putin to abandon Assad. Having repeatedly embarrassed themselves by briefing that a major change in the Russian position was imminent, there seems a growing acceptance that - for now at least - it may simply not happen.

Having agreed not to veto a U.N. Security Council resolution that led to the Western-backed overthrow of Libya's leader last year, Russia and China show no sign of letting the same thing happen again in Syria - particularly at a time when both accuse the West of encouraging their own domestic opponents.

"There ... is the glaring fact that Russia and Western and Arab powers still do not see eye to eye and cannot agree to the details of a power-sharing agreement, which diminishes the pressure in Damascus," says Anthony Skinner, head of Middle East and North Africa at political risk consultancy Maplecroft.

"These diplomatic efforts ... are on par to trying to weave a fleece from disintegrating threads."

In the short term, that disintegration could well continue.

On Saturday, Russian Foreign Minister Sergei Lavrov said that if other world powers were truly committed to the pro-opposition Friends of Syria, "we would then be in a position where we couldn't agree on anything".

In the long run, however, diplomats widely believe Assad cannot survive the array of forces against him - particularly his own people. Those from the Sunni majority now protesting or fighting know that if they lose and he reasserts his power, the crackdown will likely be devastatingly savage.

The Alawite minority who make up much of the elite of politics and the armed forces, meanwhile, will also fear the consequences of defeat. But they may ultimately decide that their best chance of survival involves ditching their leader.

When or if that happens, the diplomatic channels may reopen. In the meantime, Western powers are left wondering whether their meeting in Geneva was even worth the airfare.

"It's hard to say that it will ultimately make any difference," said Ratner at Truman Foundation.

"There is an advantage to keeping talking with the Russians and Chinese to keep diplomatic options open. But now I don't think there is much hope for an international agreement that resolves the situation."

(Editing by Alastair Macdonald)

Source: http://news.yahoo.com/diplomacy-failing-west-faces-tough-syria-choices-211254162.html

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Carly Rae Jepsen Topless Pics: Actually Destiny Benedict!


Call her clothed, people. Definitely.

A day after risque photos that purported to be of Canadian sensation Carly Rae Jepsen surfaced on the Internet, the singer's rep has denied they are actually of his client, while an often-naked model has taken credit for the images and all nipple piercings therein.

Carly Rae Jepsen Movie Premiere Pic

In response to topless photos - originally posted on Egotastic and since removed - of a young brunette who does resemble the "Call Me Maybe" artist, Jepsen's camp tells TMZ the pics in question are "200% NOT Carly," while some 21-year old named Destiny Benedict confirms the (likely planned) mix-up.

"Being mistaken for Carly Rae... Anal maybe?" Benedict Tweeted about the confusion.

Earlier this year, a similar snafu arose when a supposedly naked picture of Kim Kardashian turned out to be of model Amia Miley instead.

Man. Please tell us this isn't the new trend in desperate attention-grabbing.

[Photo: WENN.com]

Source: http://www.thehollywoodgossip.com/2012/07/carly-rae-jepsen-topless-pics-actually-destiny-benedict/

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An error-eliminating fix overcomes big problem in '3rd-gen' genome sequencing

Monday, July 2, 2012

The next "next-gen" technology in genome sequencing has gotten a major boost.

A quantitative biologist at Cold Spring Harbor Laboratory (CSHL) and collaborators today published results of experiments that demonstrate the power of so-called single-molecule sequencing, which was recently introduced but whose use has so far been limited by technical issues.

The team, led by CSHL Assistant Professor Michael Schatz and Adam Phillippy and Sergey Koren of the National Biodefense Analysis and Countermeasures Center and the University of Maryland (UMD), has developed a software package that corrects a serious problem inherent in the new sequencing technology: the fact that every fifth or sixth DNA "letter" it generates is incorrect. The high error rate is the flip side of the new method's chief virtue: it generates much longer genome "reads" than other technologies currently used, up to 100 times longer, and thus can provide a much more complete picture of genome structure than can be obtained with current, "2nd-gen" sequencing technology.

Using mathematical algorithms, Schatz and the team have preserved the great advantage of the "3rd-gen" method while all but eliminating its chief flaw. They have reduced the error rate from about 15% or greater to less than one-tenth of one percent. This mathematical "fix" ? which has been published in open-source code to the World Wide Web ? greatly increases the practical utility of 3rd-gen sequencing for the entire biomedical research community.

The team demonstrates the breadth of potential applications of single-molecule sequencing by applying their fix to sequencing tasks ranging from the tiny bacteriophage virus at one end of the difficulty scale to the large and vastly more complex genome of the parrot, at the other. The parrot genome is more than a third the size of the human genome and is published online today with the team's paper in Nature Biotechnology. The parrot sequence is "far superior to that of any previously sequenced bird genome," Schatz says.

To understand why it is better is to appreciate the advantages of 3rd-gen sequencing. The main advantage has to do with the average length of each "read" (i.e., genome segments read by a sequencer). The individual sequences are assembled into "contigs" -- shorthand for contiguous sequences -- much the way pieces in a jigsaw puzzle are assembled. In currently used 2nd-gen technology, the contigs are very small, and are massively redundant. A "consensus" version of each segment, representing the results of many layered reads, tends to be extremely accurate. But the small size of puzzle pieces prevents accurate assembly of certain genome portions, like those containing long repetitive sequences.

Obtaining superior versions of complete genomes was the objective that motivated Schatz and his collaborators, who also include HHMI Investigator Erich D. Jarvis of Duke University and CSHL Professor W. Richard McCombie, a sequencing pioneer, among others.

Combining the best of both generations

With single-molecule sequencing, the assembled contigs are much longer ? affording a much better picture of relatively larger genome segments, including those occupied by lengthy repeats. This is what Schatz and his team wanted to preserve, while at the same time boosting the error-free rate. They did so by effectively taking the best of both 2nd- and 3rd-gen technologies.

"We call our approach 'hybrid error correction,'" Schatz explains.

The team's major insight was to take advantage of the long-read data offered by a 3rd-gen machine like that used in their experiments, a Pacific Biosciences RS sequencer, and mixing in highly accurate short reads obtained from a separate 2nd-gen sequencer. The two data types were run through an open-source genome assembly program called Celera Assembler to generate a clean final assembly that has proven 99.9% error-free and composed of contigs whose median size is at least double that obtainable with 2nd-gen "short-read" sequencers. Contig sizes are expected to increase appreciably in subsequent iterations of the hybrid approach as single molecule long-read sequencing improves.

High-quality genome assemblies are especially important for genome annotation and comparative genome analyses. Many microbial genome analyses depend on finished genomes, but their cost is prohibitive using older technologies. High-quality analysis of the genomes of higher organisms depends upon continuous sequences that capture long stretches of DNA that spell out genes. Discoveries in recent years of spontaneously occurring structural changes in genomes called copy number variations -- such as those made by CSHL Professor Mike Wigler and his team in their research on schizophrenia and autism ? make clear the importance of being able to obtain clean and accurate pictures of the entire genomes of affected individuals.

With hybrid error correction, Schatz and his colleagues have "demonstrated that high error rates associated with long reads need not be a barrier to genome assembly," he summarizes. "High-error long reads can be efficiently assembled in combination with complementary short reads to produce assemblies not previously possible."

###

Cold Spring Harbor Laboratory: http://www.cshl.org

Thanks to Cold Spring Harbor Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121393/An_error_eliminating_fix_overcomes_big_problem_in___rd_gen__genome_sequencing

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Guys who like My Little Pony gather for 'BronyCon'

My Little Pony cartoon fans, some in Little Pony costumes, listen to a presentation at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. This weekend's "BronyCon Summer 2012" at the Meadowlands Exposition Center attracted 4,000 men, women, boys and girls, many in colorful wigs and costume. (AP Photo/Mel Evans)

My Little Pony cartoon fans, some in Little Pony costumes, listen to a presentation at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. This weekend's "BronyCon Summer 2012" at the Meadowlands Exposition Center attracted 4,000 men, women, boys and girls, many in colorful wigs and costume. (AP Photo/Mel Evans)

My Little Pony cartoon fans, some in Little Pony costumes, crowd isles of vendors at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. Scores of men in brightly colored costumes were among the 4,000 My Little Pony fans at this weekend?s ?BronyCon? gathering in New Jersey for fans of a My Little Pony cartoon. ?Bronies? are guys who like ?My Little Pony: Friendship is Magic". (AP Photo/Mel Evans)

Matthew Zadonia carries a stuffed animal from the My Little Pony cartoons as he stands with others at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. Scores of men in brightly colored costumes were among the 4,000 My Little Pony fans at this weekend?s ?BronyCon? gathering in New Jersey for fans of a My Little Pony cartoon. (AP Photo/Mel Evans)

Jeannine Riley, of Bethlehem, Pa., is dressed as the "My Little Pony cartoon character Pinkie Pie as she stands with Michele Moser, of Bethlehem, Pa., dressed as Rainbow Dash, while they walk at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. This weekend's "BronyCon Summer 2012" at the Meadowlands Exposition Center attracted 4,000 men, women, boys and girls, many in colorful wigs and costume. (AP Photo/Mel Evans)

Josiah Tyrrell, of Syracuse, N.Y., is dressed as the character Flam from the My Little Pony cartoons as he stands with others at ?BronyCon? Saturday, June, 30, 2012, in Secaucus, N.J. Scores of men in brightly colored costumes were among the 4,000 My Little Pony fans at this weekend?s ?BronyCon? gathering in New Jersey for fans of a My Little Pony cartoon. (AP Photo/Mel Evans)

(AP) ? Dale Fjordbotten is a proud "My Little Pony" fan, with the shiny blue body suit and yellow lightning bolt, blue wings and blue tail to prove it.

Like many "Bronies" ? boys and men who like the cartoon "My Little Pony: Friendship is Magic"? the 25-year-old college student turned out over the weekend for "BronyCon Summer 2012" at the Meadowlands Exposition Center, which drew 4,000 men, women, boys and girls, many in colorful wigs and costumes.

"I thought about what people would say. 'It's creepy. It's weird. It's a ... show for little girls,'" said Fjordbotten, from Staten Island, N.Y. "It's just a great show ... the story line, the plot, the beautiful animation."

Bronies say they're a misunderstood lot who've gotten a bad rap from the media. They're all about the show, friendship, love and tolerance, and they have no bad intentions, they say.

"I discovered that there's nothing to be ashamed of being a Brony," said 19-year-old James Penna of Mastic in Long Island, N.Y. "People are into what they're into."

Outside the convention center, young men danced and sang along with songs from My Little Pony cartoon that blasted from loud speakers as a video screen on a large truck showed the show's characters. One observer said it almost felt like a Grateful Dead concert.

Inside, vendors sold stuffed ponies, pony accessories, pony signs, pony hats and just about every pony item imaginable. Stars who do the show's voices signed autographs and gave speeches.

Staff appeared to be a little overwhelmed at times. It was just over a year ago when BronyCon attracted about 100 people to some meeting rooms in New York City. Now there are thousands of Bronies across the country.

Hasbro released the first My Little Pony toys in 1983, and they led to television specials, a film and the first TV series from 1986 to 1987.

The brand stuck around through the years. But along came animator Lauren Faust, who was hired by Hasbro and sparked new life to My Little Pony when she created the "Friendship is Magic" series.

Faust had worked on "The Powerpuff Girls" and "Foster's Home for Imaginary Friends" before dreaming up the land of Equestria, where My Little Pony characters like Twilight Sparkle, Apple Jack, Rainbow Dash and Pinkie Pie get into all kinds of adventures.

Faust told The Associated Press at BronyCon on Saturday that she never imagined the show would be such a hit with teenage boys and young men. She said her main target was little girls, but she hoped to draw in moms and perhaps some boys with strong characters and compelling story lines.

"We live in a society where saying that something is for girls is the equivalent to saying that something is stupid, or saying that something isn't worthwhile," Faust said.

"I think that's awful and I think that kind of attitude needs to be changed," she said. "And these men are doing it. ... They're proud that they're forward-thinking and modern enough to look past this misogynistic attitude."

Faust said she, like the Bronies, is disturbed at the negative images some people have about men who like the show.

"There are a lot of people who when they first hear about men watching a show for little girls, they're taken to a creepy place," she said. "They think there's something wrong with that, something devious about it. I think that's unfortunate.

"I don't think you have to have bad intentions to like little girls or to like the things that they like," Faust said. "And it's upsetting to me that people jump to those conclusions. I think it's unfair to men and I think it's unfair to girls and women."

To set the record straight about Bronies, Faust, John de Lancie and others are producing a documentary that filmed over the weekend at BronyCon. De Lancie is the voice of Discord on "My Little Pony: Friendship is Magic" and is perhaps best known for playing "Q'' on "Star Trek: The Next Generation."

Zac North traveled from his hometown of Dayton, Ohio, to be with fellow Bronies in New Jersey this weekend. He dressed as his favorite character, the antagonistic Discord, wearing a hooded and multicolored costume complete with a dragon tail, since Discord is a pony-dragon hybrid.

Why does he like the show?

"It's colorful and innocent, which is something I don't have in my life," the 26-year-old Sam's Club worker said. "I like the community away from the show."

Twenty-year-old My Little Pony fan Gabby Pantaloni of Hershey, Pa., said she was kind of shocked that so many guys like the show, as she stood in a line at BronyCon to get her picture taken with other enthusiasts dressed like her favorite character Rarity.

"After watching the show, I could see why anyone of any age would like it," she said. "I think it just makes us all feel like kids again. Some of us are afraid of growing up. We're all just kids at heart."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-07-01-Whose%20Little%20Pony/id-fed3e66a1e9d440eadd9fd9c4715c296

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Monday, July 2, 2012

Gas prices lowest since January, but oil soars

Gas prices hit a $3.35 national average ? the lowest since Jan. 6. But oil prices soared Friday, hinting that gas prices may be back on the way up.?

By Chris Kahn,?AP Energy writer / June 30, 2012

Travis Wayne provides full service at Ballinger's gas station in Memphis in this June 2012 file photo. Gas prices dropped to their lowest level since January, but oil prices are headed back up.

Jim Weber/The Commercial Appeal/AP/File

Enlarge

Oil soared the most in more than three years after European leaders took surprisingly aggressive steps to halt a debt crisis that has undermined confidence in the global economy.

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Benchmark?U.S. crude jumped by $7.27, or 9.4 percent, on Friday to end the week at $84.96 per barrel in New York. Brent crude, which helps set the?price?of imported oil, rose by $6.44, or 7 percent, to $95.51 per barrel in London.

The surge could end a nearly three-month decline in?U.S. gasoline?prices. The national average for?gas?had declined from $3.94 per gallon in the first week of April to $3.35 on Friday.

Oil rose after eurozone leaders unveiled a plan to rescue ailing banks, relieve debt-burdened governments in Italy, Spain and elsewhere and restore the confidence of markets. The progress in dealing with Europe's lengthy debt crisis is good news for that continent's ? and the world's ? economy. Economic growth drives energy consumption.

The deal was struck as borrowing rates in Spain and Italy surged to levels that were considered unsustainable. Leery investors were surprised and energized by the breakthrough ? they rushed to buy riskier assets like oil and stocks and sold ultra-safe?U.S. Treasuries. Stock in the?U.S. rose more than 2 percent, while European stock markets posted even loftier gains.

"All of a sudden we're not worried about the Spanish and Italian banks going bankrupt over the weekend," said Phil Flynn, an oil analyst with?Price?Group.

U.S. drivers might not share in oil traders' relief. Tom Kloza, publisher and chief oil analyst at Oil?PriceInformation Service, said gasoline should get a little more expensive next week as stations?price?in the jump in oil, which accounts for two-thirds of the cost of a gallon of?gas.

Oil plunged around 25 percent from May 1 through Thursday. At $3.35 per gallon, the national average was the lowest since Jan. 6, according to auto club AAA, Wright Express and OPIS.?Gas?could still fall a few cents over the weekend ? pump?prices?usually lag the action in the markets.

"That's probably the bottom until after Labor Day," Kloza said. He expects the average to waver between $3.30 and $3.50 per gallon for the rest of the summer.

Friday's percentage rise in benchmark?U.S. crude was the biggest since March 12, 2009. The dollar gain was the largest since Sept. 22, 2008.

Oil added to its ded stronger c The crisis its gains in the afternoon on reports that Norway's Statoil shut down production of another platform in the North Sea due to a tanker leak. Statoil previously said that daily production will fall 10 percent after oil workers went on strike at four North Sea fields.

North Sea oil supplies much of Europe. The loss of production will squeeze stockpiles just as Europe prepares to stop buying Iranian oil on Sunday. Europe announced an embargo earlier this year in an effort to pressure Iran to open its nuclear facilities to inspection. Western nations fear that Iran is building a nuclear weapon; Iran denies the claim.

International sanctions already have cut Iranian exports by about 700,000 barrels per day. Experts said it's unclear how much more of Iran's oil will be taken off the market once the embargo goes into effect. But a further reduction in global supply could cause oil?prices?to rise.

Friday's rise in oil?prices?boosted shares for major petroleum companies, trimming some of their losses for the quarter. On Friday, shares of BP jumped 4.7 percent, Apache Corp. rose by 2.3 percent, Exxon Mobil Corp. jumped 2.2 percent and Chevron Corp. rose by 1.4 percent.

In other futures trading, heating oil added 14.41 cents, about 6 percent, to finish at $2.696 per gallon and wholesale gasoline added 11.3 cents, or nearly 5 percent, to end at $2.7272 per gallon. Natural?gas?rose by 10.2 cents, nearly 4 percent, to finish the week at $2.824 per 1,000 cubic feet.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/adgv2cVJJS0/Gas-prices-lowest-since-January-but-oil-soars

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Google Android 4.1 "Jelly Bean"


Android 4.1 "Jelly Bean" is a solid refinement of what is now the world's most popular OS on new smartphones. While calling it 5.0 would have been a stretch, it's more significant than you'd expect for a point upgrade. For now, you can only get Android 4.1 on a few devices, including the?Samsung Galaxy Nexus ($199.99, 4 stars) and Samsung Nexus S (3.5 stars) phones, and the Google Nexus 7 ($199, 4.5 stars) and?Motorola Xoom (3.5 stars) tablets. The upgrades will roll out sometime in the middle of July as over-the-air updates. There's nothing revolutionary about Android 4.1?the new Google Now feature comes close, but it doesn't work well enough just yet. Still, there are so many minor updates and overall performance improvements that Jelly Bean adds up to our new Editors' Choice for mobile smartphone OSes.

User Interface Improvements
For this review, I tested Android 4.1 on an unlocked Samsung Galaxy Nexus. Right from the beginning, the setup process was smooth, and faster than it is with earlier Android phones. Most of the default options were already checked, for example, and I had no problem adding my existing Google account. Once you're in, the OS walks you along with a series of translucent tip screens that appear over the home screen and main menu. This hand-holding is definitely helpful if you're new to the OS, though experienced users will already know many of the tips.

There's more going on here than just minor UI refinements, though. At Google I/O, Google engineering director David Burke talked about Project Butter, which was the company's effort to improve Android performance enough that it feels "buttery" smooth in use. This effort affected many aspects of the OS, such as improved vsync timing for faster frame rates on the display itself, triple graphics buffering for preventing dropped frames in video games, and improved overall touch-screen response.

On the Galaxy Nexus, there's definitely a noticeable improvement. You can now easily resize and move around icons and widgets on each home screen panel or delete apps by swiping the icon up, which causes it to disappear. The system font ("Roboto") already looked sharp and smooth before, and still does. But menu animations, finger swipes, and scrolling now feel at least as solid as they do on iOS, and possibly even a bit better in spots. The Galaxy Nexus is no longer one of the fastest Android phones on the market, but you wouldn't know that from how nicely the unit responds with Jelly Bean loaded.

Keyboard, Web Browser, and Messaging
The new predictive keyboard is another solid upgrade. I spent quite some time typing on it, and it seemed to do a much better job than before at guessing the word I meant, even whenever I typed several letters incorrectly. The prediction function works just as it does on Apple iOS 5.1.1 (Free, 4.5 stars), in that it can figure out your left finger was slightly to the left each time, for example, and then figure out what word you meant based on that and the grammar of the sentence you're typing.

The new predictive text engine also one-ups the that of iOS on the iPhone, in that it still shows the bar beneath the text window with possible alternatives?rather than just one the way the iPhone does?and then pops it in with a little animated fade as you continue typing. These are small details, but they're beautiful in action. This is exactly the kind of polish Android needed.

The Web browser offers smooth handling of multiple tabs, which you can swipe among on a separate screen. One issue; while auto-rotate was turned off by default, when I turned it on, I noticed some pages had trouble formatting columns of text when flipping between landscape and portrait mode. In other words, the screen would be formatted correctly in one orientation, but then end up with a thin column and tons of white space in the other.

Adobe has officially dropped support for Flash, starting with Jelly Bean. This doesn't bother me as much as it bothers some other people. Even when it works on mobile devices, it doesn't really work all that well. The end of Flash for Android is hardly a surprise, at any rate, as Adobe said months ago it was discontinuing all mobile Flash development.

In the messaging app, tap the new message icon, and it pops up names and photos from your contact list as you type letters, including alternate phone numbers indented slightly as compared with the main one. I tested this function with a book of about 1,500 contacts and it was super-fast.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/T62K9UgA44Y/0,2817,2406539,00.asp

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New way to grow, isolate cancer cells may add weapon against disease

New way to grow, isolate cancer cells may add weapon against disease [ Back to EurekAlert! ] Public release date: 2-Jul-2012
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Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

CHAMPAIGN, Ill. The news a cancer patient most fears is that the disease has spread and become much more difficult to treat. A new method to isolate and grow the most dangerous cancer cells could enable new research into how cancer spreads and, ultimately, how to fight it.

University of Illinois researchers, in collaboration with scientists at the Huazhong University of Science and Technology in China, published their results in the journal Nature Materials.

"This may open the door for understanding and blocking metastatic colonization, the most devastating step in cancer progression," said Ning Wang, a professor of mechanical science and engineering who co-led the study.

The most dangerous cancer cells are the ones that can break away from the primary tumor and travel through the body to form a new tumor in another tissue, a process called metastasis. Fortunately, only a small percentage of cancer cells have the ability to become new tumors. Unfortunately, the tumor-seeding cells are the ones hardest to kill with chemotherapy and it only takes a lone survivor to mount a resurgence.

Cancer researchers have theorized that these elusive tumor-spreading cells may be responsible for recurrences after surgery or treatment. They are very interested in studying these cells in hopes of better understanding and ultimately combating them. However, identifying and isolating metastatic cells from a general cancer cell population is very difficult.

One hotly debated question is whether metastatic cells share characteristics of stem cells, and if so, to what extent. Some studies have found cancer cells with stem-cell markers, others have displayed stem-cell-like behavior, and yet others have suggested that cells can spontaneously switch from a primary cancer cell to a stem-cell-like cancer cell and back.

Wang's group at the U. of I. had previously found that stem cells grow better in a soft gel than on a rigid plate. They wondered if this principle would also apply to cancer-spreading cells, since they share some other qualities of stem cells. So they suspended single cells of mouse melanoma, a type of skin cancer, in soft gel made of fibrin, a fiber-like protein found throughout the body. They cultured the cells into colonies and compared them with those grown on a stiff flat surface, the traditional method used by cancer researchers.

After five days, the soft gels were riddled with spheres of soft cells, many more colonies than grew on the harder surface. In addition, the cells were softer and grew in spherical clumps unusual for most cancer cells, but signature characteristics of stem cells.

"Starting from single cells, by day five, you have more cells in the soft substrate proliferating," Wang said. "This is exactly the opposite from most cancer cells, which prefer a stiffer substrate. But these cells like to grow in the soft environment. Why is this important? Because they turn into tumors."

The researchers found that the cells grown in the 3-D soft fibrin were much more efficient at causing tumors in mice than cells prepared traditionally. In fact, injecting as few as 10 cells from a culture grown in a soft gel was sufficient to induce tumors in a large percentage of mice, while 10,000 cells from a traditional culture are needed to achieve results with the same incidence of cancer. This suggests that, while a traditional culture of cells has only a few capable of starting new tumors, the soft substrate method is capable of isolating these cells and promoting the growth and multiplication of these cells in culture.

The researchers then tested their soft fibrin substrate with other cancer cell lines and found that they also formed stem-cell-like colonies of highly tumorigenic cells, showing that the process is generalizable for many types of cancer. The cells grown in a soft gel even caused tumors in normal mice, called "wild-type," rather than only the immune-compromised mice typically needed for such studies.

The researchers also found that the tumor-repopulating cells express a self-renewal gene called Sox2, which is usually only expressed in stem cells and not in traditionally prepared cancer cells. When the researchers blocked the Sox2 gene, the cells started to differentiate, becoming traditional tissue-specific cancer cells.

Now, the researchers will continue exploring the molecular mechanisms that make these tumor-seeding cells so good at surviving in distant organs and so efficient at seeding tumors. They hope that knowledge will contribute to treatments to stop the spread of cancer.

"Since these cells are more resistant to current cancer-killing drugs than differentiated cancer cells, we would like to see if there are ways to identify and develop new molecules and methods that can specifically target and kill these cells," Wang said.

###

Editor's note: To contact Ning Wang, call 217-265-0913; email nwangrw@illinois.edu.

The paper, "Soft Fibrin Gels Promote Selection and Growth of Tumorigenic Cells," is available online at http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3361.html.


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New way to grow, isolate cancer cells may add weapon against disease [ Back to EurekAlert! ] Public release date: 2-Jul-2012
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Contact: Liz Ahlberg
eahlberg@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign

CHAMPAIGN, Ill. The news a cancer patient most fears is that the disease has spread and become much more difficult to treat. A new method to isolate and grow the most dangerous cancer cells could enable new research into how cancer spreads and, ultimately, how to fight it.

University of Illinois researchers, in collaboration with scientists at the Huazhong University of Science and Technology in China, published their results in the journal Nature Materials.

"This may open the door for understanding and blocking metastatic colonization, the most devastating step in cancer progression," said Ning Wang, a professor of mechanical science and engineering who co-led the study.

The most dangerous cancer cells are the ones that can break away from the primary tumor and travel through the body to form a new tumor in another tissue, a process called metastasis. Fortunately, only a small percentage of cancer cells have the ability to become new tumors. Unfortunately, the tumor-seeding cells are the ones hardest to kill with chemotherapy and it only takes a lone survivor to mount a resurgence.

Cancer researchers have theorized that these elusive tumor-spreading cells may be responsible for recurrences after surgery or treatment. They are very interested in studying these cells in hopes of better understanding and ultimately combating them. However, identifying and isolating metastatic cells from a general cancer cell population is very difficult.

One hotly debated question is whether metastatic cells share characteristics of stem cells, and if so, to what extent. Some studies have found cancer cells with stem-cell markers, others have displayed stem-cell-like behavior, and yet others have suggested that cells can spontaneously switch from a primary cancer cell to a stem-cell-like cancer cell and back.

Wang's group at the U. of I. had previously found that stem cells grow better in a soft gel than on a rigid plate. They wondered if this principle would also apply to cancer-spreading cells, since they share some other qualities of stem cells. So they suspended single cells of mouse melanoma, a type of skin cancer, in soft gel made of fibrin, a fiber-like protein found throughout the body. They cultured the cells into colonies and compared them with those grown on a stiff flat surface, the traditional method used by cancer researchers.

After five days, the soft gels were riddled with spheres of soft cells, many more colonies than grew on the harder surface. In addition, the cells were softer and grew in spherical clumps unusual for most cancer cells, but signature characteristics of stem cells.

"Starting from single cells, by day five, you have more cells in the soft substrate proliferating," Wang said. "This is exactly the opposite from most cancer cells, which prefer a stiffer substrate. But these cells like to grow in the soft environment. Why is this important? Because they turn into tumors."

The researchers found that the cells grown in the 3-D soft fibrin were much more efficient at causing tumors in mice than cells prepared traditionally. In fact, injecting as few as 10 cells from a culture grown in a soft gel was sufficient to induce tumors in a large percentage of mice, while 10,000 cells from a traditional culture are needed to achieve results with the same incidence of cancer. This suggests that, while a traditional culture of cells has only a few capable of starting new tumors, the soft substrate method is capable of isolating these cells and promoting the growth and multiplication of these cells in culture.

The researchers then tested their soft fibrin substrate with other cancer cell lines and found that they also formed stem-cell-like colonies of highly tumorigenic cells, showing that the process is generalizable for many types of cancer. The cells grown in a soft gel even caused tumors in normal mice, called "wild-type," rather than only the immune-compromised mice typically needed for such studies.

The researchers also found that the tumor-repopulating cells express a self-renewal gene called Sox2, which is usually only expressed in stem cells and not in traditionally prepared cancer cells. When the researchers blocked the Sox2 gene, the cells started to differentiate, becoming traditional tissue-specific cancer cells.

Now, the researchers will continue exploring the molecular mechanisms that make these tumor-seeding cells so good at surviving in distant organs and so efficient at seeding tumors. They hope that knowledge will contribute to treatments to stop the spread of cancer.

"Since these cells are more resistant to current cancer-killing drugs than differentiated cancer cells, we would like to see if there are ways to identify and develop new molecules and methods that can specifically target and kill these cells," Wang said.

###

Editor's note: To contact Ning Wang, call 217-265-0913; email nwangrw@illinois.edu.

The paper, "Soft Fibrin Gels Promote Selection and Growth of Tumorigenic Cells," is available online at http://www.nature.com/nmat/journal/vaop/ncurrent/full/nmat3361.html.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/uoia-nwt070212.php

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