Obama: Northern Ireland peace will be tested

President Barack Obama gestures during a speech at the Belfast Waterfront Hall on Monday June 17, 2013, in Belfast, Northern Ireland. Obama is attending the G-8 summit in Enniskillen, Northern Ireland where leaders are expected to discuss the ongoing conflict in Syria, and free-trade issues. (AP Photo/Evan Vucci)

President Barack Obama gestures during a speech at the Belfast Waterfront Hall on Monday June 17, 2013, in Belfast, Northern Ireland. Obama is attending the G-8 summit in Enniskillen, Northern Ireland where leaders are expected to discuss the ongoing conflict in Syria, and free-trade issues. (AP Photo/Evan Vucci)

US President Barack Obama, left, and his wife Michelle Obama wave after he delivered a keynote address ahead of the G-8 summit at Waterfront Hall in Belfast, Northern Ireland on Monday, June 17, 2013. (AP Photo/ Paul Faith, Pool)

President Barack Obama waves as he arrives to deliver a speech at the Belfast Waterfront Hall on Monday June 17, 2013, in Belfast, Northern Ireland. Obama is attending the G-8 summit in Enniskillen, Northern Ireland where leaders are expected to discuss the ongoing conflict in Syria, and free-trade issues. (AP Photo/Evan Vucci)

US President Barack Obama delivers a keynote address ahead of the G-8 summit at Waterfront Hall in Belfast, Northern Ireland on Monday, June 17, 2013. (AP Photo/ Paul Faith, Pool)

US President Barack Obama, second left, his wife Michelle, second right, and daughters Sasha, front, and Malia, first right, are greeted by Joan Christie, left, The Queen's official representative in County Antrim, upon arrival at Belfast International Airport, Northern Ireland, on Monday, June 17, 2013. President Obama is in Northern Ireland to attend the G8 Summit in Enniskillen. (AP Photo/ Peter Muhly, Pool)

ENNISKILLEN, Northern Ireland (AP) ? President Barack Obama declared peace in Northern Ireland a "blueprint" for those living amid conflict around the world, while acknowledging that the calm between Catholics and Protestants will face further tests. Summoning young people to take responsibility for their country's future, Obama warned there is "more to lose now than there's ever been."

"The terms of peace may be negotiated by political leaders, but the fate of peace is up to each of us," Obama said Monday during remarks at Belfast's Waterfront Hall. The glass-fronted building would never have been built during the city's long era of car bombs.

Obama arrived in Northern Ireland Monday morning after an overnight flight from Washington. Following his speech to about 1,800 students and adults, he flew to a lakeside golf resort near Enniskillen, passing over a sweeping patchwork of tree-lined farms as he prepared to meet with other leaders of the Group of 8 industrial nations on Syria, trade and counterterrorism. One-on-one meetings with Russian President Vladimir Putin, British Prime Minister David Cameron and Italian Prime Minister Enrico Letta were all on the agenda for Monday.

Cameron selected Enniskillen as the site of this year's meeting as a way to highlight Northern Ireland's ability to leave behind a four-decade conflict that claimed 3,700 lives.

Significant progress has been made in the 15 years since the U.S.-brokered Good Friday Accords, including a Catholic-Protestant government and the disarmament of the IRA and outlawed Protestant groups responsible for most of the 3,700 death toll. But tearing down Belfast's nearly 100 "peace lines" ? barricades of brick, steel and barbed wire that divide neighborhoods, roads and even one Belfast playground ? is still seen by many as too dangerous. Obama cited that playground in his speech, lauding an activist whose work led to the opening of a pedestrian gate in the fence.

Acknowledging the reality of a sometimes-fragile peace, Obama recalled the Omagh bombings that killed 29 people and injured hundreds more. It was the deadliest attack of the entire conflict and occurred after the Good Friday deal.

Peace will be tested again, Obama said in Belfast.

"Whenever your peace is attacked, you will have to choose whether to respond with the same bravery that you've summoned so far or whether you succumb to the worst instincts, those impulses that kept this great land divided for too long. You'll have to choose whether to keep going forward, not backward," he said.

Last month, the Catholic and Protestant leaders of Northern Ireland's unity government announced a bold but detail-free plan to dismantle all peace lines by 2023. British Prime Minister David Cameron formally backed the goal Friday, and Obama followed with his own endorsement Monday.

The president specifically endorsed an end to segregated housing and schools, calling it an essential element of lasting peace.

"If towns remain divided ? if Catholics have their schools and buildings, and Protestants have theirs, if we can't see ourselves in one another, if fear or resentment are allowed to harden ? that too encourages division. It discourages cooperation," Obama said.

One symbol of that effort to end the segregation was on display as Obama spoke to an audience that brought together students from both faiths, effectively integrating Northern Ireland's schoolchildren if just for a morning.

Drawing on America's own imperfect battle with segregation, Obama recalled how a century after the U.S. Civil War, the nation he leads is still not fully united. His own parents ? a white woman from Kansas and a black man from Kenya ? would not have been able to marry in some states, Obama said, and he would have had a hard time casting a ballot, let alone running for office.

"But over time, laws changed, and hearts and minds changed, sometimes driven sometimes by courageous lawmakers, but more often driven by committed citizens," he said.

Though Obama did not specifically mention Syria, his remarks on Northern Ireland recalled the fierce conflict there that has so far resulted in 93,000 deaths. For those looking for a way out of conflict, Obama said Northern Ireland is "proof of what is possible."

Obama and other G-8 leaders were expected to discuss Syria Monday night over a working dinner. Obama will be looking to Britain and France to join him in sending weapons to the Syrian opposition.

Casting a shadow over the summit are new revelations by the Guardian newspaper that the British eavesdropping agency GCHQ repeatedly hacked into foreign diplomats' phones and emails when the U.K. hosted international conferences, including a 2009 Group of 20 summit in London. The report follows recent disclosures about the U.S. government's own surveillance programs and could lead to awkward conversation as the leaders open another international gathering that Britain is hosting.

Despite an agenda devoted to trade, economic growth and international tax issues, the G-8 will be eclipsed by discussions over how to address the two-year-old civil war in Syria and the decision by the United States to begin supplying rebels with military aid.

Obama's meeting with Russia's Putin later Monday will highlight the rift between their countries in addressing fierce fighting in Syria. While Putin has called for negotiated peace talks, he has not called for Syrian President Bashar Assad to leave power, and he remains one of Assad's strongest political and military allies.

In a likely preview of his discussions with Obama, Putin defended Russia's continuing supply of weapons to Assad's military in a meeting Sunday with Cameron, the British leader.

Putin said Russia was providing arms "to the legitimate government of Syria in full conformity with the norms of international law."

The White House is not expecting any breakthrough with Putin on Syria during Putin's meeting with Obama.

Obama is making his first visit to Northern Ireland, though he visited the neighboring Republic of Ireland in 2011. That trip included a public speech in the center of Dublin, as well as a stop in the village of Moneygall, where Obama's great-great-great grandfather was born. The president called that visit "magical."

First lady Michelle Obama and daughters Malia and Sasha, who also made the trip from Washington, were to spend Monday and Tuesday in Dublin while the president attended the G-8 summit. Later Tuesday, the first family departs for Germany, where the president will meet with Chancellor Angela Merkel and speak at the Brandenburg Gate.

___

Associated Press writer Julie Pace in Sligo, Ireland and Shawn Pogatchnik in Enniskillen, Northern Ireland contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-06-17-EU-Obama/id-7b3e0f60acae4f199e56c8b81d93589a

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'Undruggable' cancer may be druggable after all: New target identified

June 17, 2013 ? Harvard Stem Cell Institute (HSCI) researchers have identified in the most aggressive forms of cancer a gene known to regulate embryonic stem cell self-renewal, beginning a creative search for a drug that can block its activity.

The gene, SALL4, gives stem cells their ability to continue dividing as stem cells rather than becoming mature cells. Typically, cells only express SALL4 during embryonic development, but the gene is re-expressed in nearly all cases of acute myeloid leukemia and 10 to 30 percent of liver, lung, gastric, ovarian, endometrial, and breast cancers, strongly suggesting it plays a role in tumor formation.

In work published in the New England Journal of Medicine, two HSCI-affiliated labs -- one in Singapore and the other in Boston -- show that knocking out the SALL4 gene in mouse liver tumors, or interfering with the activity of its protein product with a small inhibitor, treats the cancer.

"Our paper is about liver cancer, but it is likely true about lung cancer, breast cancer, ovarian cancer, many, many cancers," said HSCI Blood Diseases Program leader Daniel Tenen, who also heads a laboratory at the Cancer Science Institute of Singapore (CSI Singapore). "SALL4 is a marker, so if we had a small molecule drug blocking SALL4 function, we could also predict which patients would be responsive."

Studying the therapeutic potential of a transcription factor is unusual in the field of cancer research. Transcription factors are typically avoided because of the difficulty of developing drugs that safely interfere with genetic targets. Most cancer researchers focus their attention on kinases.

The HSCI researchers' inquiry into the basic biology of the SALL4 gene, however, revealed another way to interfere with its activity in cancer cells. The gene's protein product is responsible for turning off a tumor-suppressor gene, causing the cell to divide uncontrollably. Using this knowledge, the researchers demonstrated that targeting the SALL4 protein with druglike molecules could halt tumor growth. "The pharmaceutical companies decided that if it is not a kinase and it is not a cell surface molecule, then it is 'undruggable,' " Tenen said. "To me, if you say anything is 'undoable,' you are limiting yourself as a biomedical scientist."

Earlier this year, Tenen's co-author, HSCI-affiliated faculty member Li Chai, a Harvard Medical School assistant professor of pathology at Brigham and Women's Hospital, published a paper in the journal Blood, reporting that a SALL4 inhibitor has similar treatment potential in leukemia cells.

Chai took blood samples from patients with acute myeloid leukemia, treated the leukemic cells with the inhibitor that interferes with SALL4 protein activity, and then transplanted the blood into mice. The result was a gradual regression of the same cancer in mice.

"I am excited about being on the front line of this new drug development," Chai said. "As a physician-scientist, if I can find a new class of drug that has very low toxicity to normal tissues, my patients can have a better quality of life."

Chai and Tenen are now working with HSCI Executive Committee member Lee Rubin, the Harvard Institute of Chemistry and Cell Biology, and James Bradner of Dana-Farber Cancer Institute, another HSCI-affiliated faculty member, to overcome the technical challenges of drug development and demonstrate the potential of SALL4 interference to treat other forms of cancer.

"I think as academics, we seek to engage drug companies because they can do these types of things better than we can," Tenen said. "But, also as an academic, I want to go after the important biologic targets that are not being sought after by the typical drug company -- because if we do not, who will?"

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/a2W8tEIg928/130617173135.htm

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To ease shortage of organs, grow them in a lab?

NEW YORK (AP) ? By the time 10-year-old Sarah Murnaghan finally got a lung transplant last week, she'd been waiting for months, and her parents had sued to give her a better shot at surgery.

Her cystic fibrosis was threatening her life, and her case spurred a debate on how to allocate donor organs. Lungs and other organs for transplant are scarce.

But what if there were another way? What if you could grow a custom-made organ in a lab?

It sounds incredible. But just a three-hour drive from the Philadelphia hospital where Sarah got her transplant, another little girl is benefiting from just that sort of technology. Two years ago, Angela Irizarry of Lewisburg, Pa., needed a crucial blood vessel. Researchers built her one in a laboratory, using cells from her own bone marrow. Today the 5-year-old sings, dances and dreams of becoming a firefighter ? and a doctor.

Growing lungs and other organs for transplant is still in the future, but scientists are working toward that goal. In North Carolina, a 3-D printer builds prototype kidneys. In several labs, scientists study how to build on the internal scaffolding of hearts, lungs, livers and kidneys of people and pigs to make custom-made implants.

Here's the dream scenario: A patient donates cells, either from a biopsy or maybe just a blood draw. A lab uses them, or cells made from them, to seed onto a scaffold that's shaped like the organ he needs. Then, says Dr. Harald Ott of Massachusetts General Hospital, "we can regenerate an organ that will not be rejected (and can be) grown on demand and transplanted surgically, similar to a donor organ."

That won't happen anytime soon for solid organs like lungs or livers. But as Angela Irizarry's case shows, simpler body parts are already being used as researchers explore the possibilities of the field.

Just a few weeks ago, a girl in Peoria, Ill., got an experimental windpipe that used a synthetic scaffold covered in stem cells from her own bone marrow. More than a dozen patients have had similar operations.

Dozens of people are thriving with experimental bladders made from their own cells, as are more than a dozen who have urethras made from their own bladder tissue. A Swedish girl who got a vein made with her marrow cells to bypass a liver vein blockage in 2011 is still doing well, her surgeon says.

In some cases the idea has even become standard practice. Surgeons can use a patient's own cells, processed in a lab, to repair cartilage in the knee. Burn victims are treated with lab-grown skin.

In 2011, it was Angela Irizarry's turn to wade into the field of tissue engineering.

Angela was born in 2007 with a heart that had only one functional pumping chamber, a potentially lethal condition that leaves the body short of oxygen. Standard treatment involves a series of operations, the last of which implants a blood vessel near the heart to connect a vein to an artery, which effectively rearranges the organ's plumbing.

Yale University surgeons told Angela's parents they could try to create that conduit with bone marrow cells. It had already worked for a series of patients in Japan, but Angela would be the first participant in an American study.

"There was a risk," recalled Angela's mother, Claudia Irizarry. But she and her husband liked the idea that the implant would grow along with Angela, so that it wouldn't have to be replaced later.

So, over 12 hours one day, doctors took bone marrow from Angela and extracted certain cells, seeded them onto a 5-inch-long biodegradable tube, incubated them for two hours, and then implanted the graft into Angela to grow into a blood vessel.

It's been almost two years and Angela is doing well, her mother says. Before the surgery she couldn't run or play without getting tired and turning blue from lack of oxygen, she said. Now, "she is able to have a normal play day."

This seed-and-scaffold approach to creating a body part is not as simple as seeding a lawn. In fact, the researchers in charge of Angela's study had been putting the lab-made blood vessels into people for nearly a decade in Japan before they realized that they were completely wrong in their understanding of what was happening inside the body.

"We'd always assumed we were making blood vessels from the cells we were seeding onto the graft," said Dr. Christopher Breuer, now at Nationwide Children's Hospital in Columbus, Ohio. But then studies in mice showed that in fact, the building blocks were cells that migrated in from other blood vessels. The seeded cells actually died off quickly. "We in essence found out we had done the right thing for the wrong reasons," Breuer said.

Other kinds of implants have also shown that the seeded cells can act as beacons that summon cells from the recipient's body, said William Wagner, director of the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. Sometimes that works out fine, but other times it can lead to scarring or inflammation instead, he said. Controlling what happens when an engineered implant interacts with the body is a key challenge, he said.

So far, the lab-grown parts implanted in people have involved fairly simple structures ? basically sheets, tubes and hollow containers, notes Anthony Atala of Wake Forest University whose lab also has made scaffolds for noses and ears. Solid internal organs like livers, hearts and kidneys are far more complex to make.

His pioneering lab at Wake Forest is using a 3-D printer to make miniature prototype kidneys, some as small as a half dollar, and other structures for research. Instead of depositing ink, the printer puts down a gel-like biodegradable scaffold plus a mixture of cells to build a kidney layer by layer. Atala expects it will take many years before printed organs find their way into patients.

Another organ-building strategy used by Atala and maybe half a dozen other labs starts with an organ, washes its cells off the inert scaffolding that holds cells together, and then plants that scaffolding with new cells.

"It's almost like taking an apartment building, moving everybody out ... and then really trying to repopulate that apartment building with different cells," says Dr. John LaMattina of the University of Maryland School of Medicine. He's using the approach to build livers. It's the repopulating part that's the most challenging, he adds.

One goal of that process is humanizing pig organs for transplant, by replacing their cells with human ones.

"I believe the future is ... a pig matrix covered with your own cells," says Doris Taylor of the Texas Heart Institute in Houston. She reported creating a rudimentary beating rat heart in 2008 with the cell-replacement technique and is now applying it to a variety of organs.

Ott's lab and the Yale lab of Laura Niklason have used the cell-replacement process to make rat lungs that worked temporarily in those rodents. Now they're thinking bigger, working with pig and human lung scaffolds in the lab. A human lung scaffold, Niklason notes, feels like a handful of Jell-O.

Cell replacement has also worked for kidneys. Ott recently reported that lab-made kidneys in rats didn't perform as well as regular kidneys. But, he said, just a "good enough organ" could get somebody off dialysis. He has just started testing the approach with transplants in pigs.

Ott is also working to grow human cells on human and pig heart scaffolds for study in the laboratory.

There are plenty of challenges with this organ-building approach. One is getting the right cells to build the organ. Cells from the patient's own organ might not be available or usable. So Niklason and others are exploring genetic reprogramming so that, say, blood or skin cells could be turned into appropriate cells for organ-growing.

Others look to stem cells from bone marrow or body fat that could be nudged into becoming the right kinds of cells for particular organs. In the near term, organs might instead be built with donor cells stored in a lab, and the organ recipient would still need anti-rejection drugs.

How long until doctors start testing solid organs in people? Ott hopes to see human studies on some lab-grown organ in five to 10 years. Wagner calls that very optimistic and thinks 15 to 20 years is more realistic. Niklason also forecasts two decades for the first human study of a lung that will work long-term.

But LaMattina figures five to 10 years might be about right for human studies of his specialty, the liver.

"I'm an optimist," he adds. "You have to be an optimist in this job."

___

Michael Rubinkam in Lewisburg, Pa., and Allen Breed in Winston-Salem, N.C., contributed to this story.

___

Online:

Ott lab: http://ottlab.mgh.harvard.edu/

Atala lab: http://www.wakehealth.edu/WFIRM/

___

Malcolm Ritter can be followed at http://twitter.com/malcolmritter

Source: http://news.yahoo.com/ease-shortage-organs-grow-them-lab-073556092.html

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Detroit Tigers Beat Minnesota Twins 5-2 With Doug Fister, Torii Hunter Hits 300th Home Run (VIDEO)

MINNEAPOLIS -- Doug Fister held Minnesota hitless until the sixth inning and Torii Hunter connected for his 300th career home run, leading the Detroit Tigers over the Twins 5-2 Sunday.

Fister (6-4) didn't allow a baserunner until walking Ryan Doumit with two outs in the fourth inning, then lost his no-hit bid when Brian Dozier led off the sixth with a homer.

Fister allowed two runs and two hits ? both to Dozier ? in 7 2-3 innings. He struck out seven, walked two and won for the first time in his last six starts.

Joaquin Benoit pitched the final 1 1-3 innings, earning his fourth save.

Hunter and Austin Jackson both hit two-run homers for Detroit.

P.J. Walters (2-2) gave up four runs on nine hits and three walks in 5 1-3 innings.

Minnesota tried to rally with two outs in the eighth as Dozier doubled and Pedro Florimon walked to chase Fister after 110 pitches. Clete Thomas followed with an RBI single off Benoit, but Joe Mauer flied out to strand a pair of runners.

Benoit pitched a perfect ninth. Regular Tigers closer Jose Valverde warmed up alongside Benoit in the eighth, though he pitched in a non-save situation on Friday and blew his last save opportunity Wednesday at Kansas City.

Detroit jumped ahead early when Jackson led off with a single and Hunter followed with his first home runs since May 26, also against Minnesota.

The former Twins outfielder hit 192 of his career homers during his nine seasons with Minnesota. Hunter added an RBI double in the eighth.

Jackson's fourth-inning homer was his first since April 28, giving him multiple hits in back-to-back games for the first time since mid-April. The Detroit center fielder returned to the lineup Friday after missing more than a month with a strained left hamstring.

Detroit catcher Alex Avila snapped an 0-for-19 skid with a second-inning double and singled in his next at-bat, marking just his third extra-base hit and second multi-hit game since May 10. Avila left the game in the ninth inning after being hit in the left hand by a pitch from Brian Duensing.

NOTES: Twins OF Josh Willingham was out of the lineup after receiving a cortisone shot in his balky left knee after Saturday's game. He expects to return to the lineup on Tuesday. ... Tigers manager Jim Leyland reiterated his concern with Anibal Sanchez's reduced velocity on his return from shoulder tightness on Saturday following an 11-day layoff. "It just didn't look right," Leyland said Sunday. Sanchez said he felt fine after the game. ... Minnesota has an off-day Monday before hosting a three-game series against the White Sox. Mike Pelfrey (3-6, 6.12 ERA) will start Tuesday for the Twins. Pelfrey is 0-3 in his last seven starts. Dylan Axelrod (3-4, 4.26) will counter for Chicago, looking to rebound from allowing a season high-tying six earned runs to Toronto in his last outing. . Detroit returns home to begin a series Monday against Baltimore. The Tigers will send Max Scherzer (9-0, 3.19) to the mound. Scherzer gave up three earned runs and struck out 10 Orioles in a no-decision at Baltimore on May 31. Jason Hammel (7-4, 5.24) will start for the Orioles. Hammel allowed served up a season-high three homers and five runs in a season-low three innings vs. Detroit on June 1.

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Source: http://www.huffingtonpost.com/2013/06/16/detroit-tigers-minnesota-twins-doug-fister_n_3451194.html

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Phil Mickelson leads after 3rd round at US Open

ARDMORE, Pa. (AP) ? For all those runner-up finishes, with so much heartache chasing the major he covets, Phil Mickelson has never had a better chance to win the U.S. Open.

It's the first time he has ever had the outright lead going into the final round. Of the nine players within five shots, only one has the experience of winning a major. And Tiger Woods went from contender to middle-of-the-pack by matching his worst U.S. Open score as a pro.

Despite a bogey on the final hole at Merion ? the 18th was so tough it didn't yield a single birdie in the third round ? Mickelson was the sole survivor to par Saturday with an even-par 70 that gave him a one-shot lead over Hunter Mahan, Steve Stricker and former Masters champion Charl Schwartzel.

Mickelson celebrates his 43rd birthday Sunday ? on Father's Day, no less. He left Merion on Monday and didn't return until three hours before his tee time on Thursday so he could attend the eighth-grade graduation of his oldest daughter.

"It's got the makings to be something special," Mickelson said. "But I still have to go out and perform, and play some of my best golf."

He has been good enough to play 54 holes in 1-under 209.

And he was close to perfection when he stood on the par-3 17th hole with a 4-iron in his hand, 253 yards away from the orange wicker basket attached to the pin, the signature look at Merion. He was one shot behind Luke Donald until a pure swing and an 8-foot birdie putt gave him the lead.

"I just stood and admired it," Mickelson said. "It was one of the best shots I've ever hit. I mean, it just was right down the center of the green and I was hoping it would kind of get the right bounces. It left me a beautiful uphill putt that I could be aggressive with and I made it. That was fun to do that because that's just not a hole you expect to get one back."

Four others players who had been under par late in the round couldn't hang on.

Donald twice made poor swings with a 2-iron, and it cost him three shots. Mahan, Schwartzel and Justin Rose all finished bogey-bogey.

There was trouble everywhere at Merion, and it didn't take much to find it. One swing cost Ian Poulter, who drove out-of-bounds on the 15th. One decision cost Nicolas Colsaerts, who tried to hit a shot under a tree on the 18th and made triple bogey. That left Mickelson alone at the top for only the second time in a major ? he won the 2006 Masters with the lead.

The U.S. Open, however, has been nothing but trouble for Lefty.

"I don't think I feel any more pressure than anybody else who wants to win ... the U.S. Open," Mickelson said. "This is a tournament for years I've had opportunities, I've come close to, and it would mean a lot tomorrow if I could play some of my best golf ? certainly if I can play the way I have been."

Saturday was more about weeding out the pretenders for this U.S. Open ? and one of them turned out to be Woods. He started out just four shots out of the lead, and made a bending, 12-foot birdie putt on the opening hole. It never got any better for the world's No. 1 player. He made seven bogeys the rest of the way and didn't add another birdie. It was the fourth time he shot 76 in the U.S. Open, but never when he started out so close to the lead. Now, he's 10 shots behind.

"It certainly is frustrating," said Woods, who has been stuck on 14 majors since winning the 2008 U.S. Open at Torrey Pines. "I'm playing well enough to do it, and unfortunately just haven't gotten it done."

The final hour might have been a sneak preview for Sunday. At one point, there were five players under par, and suddenly there was only Mickelson.

Donald made double bogey on the 18th hole from the middle of the fairway, trying to swing too hard on a 2-iron to get up the hill and beyond the false front of the green. He wound up in ankle-deep rough, so gnarly that his third shot squirted across the green and into more thick grass.

"I should have done better," Donald said. "It was disappointing, but I'll take the positives out of today ? a really solid 16 holes of golf, and I'm only two back."

Mahan let his spectacular back nine filled with four birdies go to waste with a bogey-bogey finish for a 69. He will be in the final group for the first time in a major with Mickelson, whom he considers a close friend.

"It's going to be a very, very exciting finish," Mahan said, "because I don't think any lead is safe."

Stricker made a 10-foot par putt on the 18th hole to complete a 70 and perhaps the steadiest round of the day. His only mistake in a round that lasted 5? hours under sunshine was a tee shot into the water on the par-3 ninth for a double bogey. At 46, Stricker can become the oldest U.S. Open champion.

"I've got to play smart golf ... not make any mistakes," he said. "I think that's the biggest thing. And it's a course where it's tough to come back."

Billy Horschel, tied with Mickelson at the start of the third round, kept his emotions in check and shot 72. He was two shots behind, along with Donald and Rose

The third round featured so much movement, and so many wild swings, that seven players had a share of the lead at some point. Even though USGA executive director Mike Davis said the course was set up to allow for good scores, this was more about hanging on for dear life.

There was no faking it Saturday afternoon.

Thirty players were separated by only five shots at the start of the third round. By the end of the day, there were just 10 players separated by five shots, including amateur Michael Kim. He was tied for third until losing four shots on the last three holes.

For all the talk about Merion being just a short course, the final two holes were beastly ? 253 yards for a par 3 surrounded by deep bunkers and framed by the Scottish broom grass, and then a 530-yard closing hole up the hill, deep rough on both sides with bogeys or worse waiting for a single missed shot.

Stricker, remarkably, played bogey-free on the back nine. Horschel, striving for perfection at a championship that doesn't allow for it, dropped only one shot.

"Seventeen and 18, you've got to buckle up and hit good shots," Horschel said. "So I think tomorrow, with the pressure being on, those holes will stick out even more."

Mickelson chose not to carry a driver, and he had to be flawless again on the long closing hole. He swung the 3-wood with confidence throughout the back nine and drilled another. With some 250 yards left, another fairway metal took him just over the green. His chip came out some 10 feet short and he missed the par putt to end a streak of 12 holes without a bogey.

But he still had the lead. It was the first time only one player remained under par through 54 holes at the U.S. Open since 2007 at Oakmont, when there was none. Mickelson was tied for the 54-hole lead at Winged Foot in 2006, where he lost a one-shot lead on the final hole by making double bogey.

Of his five runner-up finishes, that one stung the most.

But he's back for another try to win his national championship. The challenge has never been more severe ? not from any player, but from Merion.

Mickelson has one piece of history working against him. In the four previous U.S. Opens at this classic course, no one with the lead going into the final round has ever gone on to win.

"I love being in the thick of it," Mickelson said. "I've had opportunities in years past, and it has been so fun, even though it's been heart-breaking to come so close a number of times and let it slide. But I feel better equipped than I have ever felt heading into the final round of a U.S. Open."

Source: http://news.yahoo.com/phil-mickelson-leads-3rd-round-us-open-001943070.html

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Debbie Gisonni: 5 Ways to Enjoy Your Summer Vacation

Get Healthy Living Alerts:

Vacations give us a much-needed break from work and responsibilities. They're a time to have fun, new adventures, rest and relaxation. In our fast-paced, over-scheduled and stress-filled lives, we often overlook the value of these benefits.

Here are five ways to ensure that you enjoy your summer vacation.

1. Always use your vacation time.

Compared to most countries, American employees have less paid vacation days, so it's amazing that some of us actually don't use what little vacation time we have! If you're all about work and no play, you are surely headed for a burnout down the road. You can't have an enjoyable vacation if you choose not to have one at all.

2. Define vacation on your own terms.

You don't have to take a trip, spend a lot of money, or even leave your house to have a vacation. All you need to do is take a break from your normal routine or work. If you happen to travel on your job, a staycation may be the perfect retreat for you. Or perhaps you'd like to spend your free time taking a pottery class, planting a garden, reading a good novel, spending time with friends and family, or just listening to the birds sing while you gently swing in your backyard hammock. A vacation is a frame of mind, not a place or schedule.

3. Do your research.

If you do plan on taking a trip, make sure there are no unpleasant surprises when you get there. Call and ask in advance to find out about things like kid-friendly or pet-friendly accommodations, transportation services, safety, climate, etc. There are plenty of travel books and Internet sites that provide all the necessary information to make your trip a pleasant one. Or, you can take the old-fashioned approach and book your travel arrangements through an experienced and knowledgeable travel agent or tour company.

4. Relax and enjoy.

Don't treat your vacation like a work project. Too much planning, organizing, list-making and over-scheduling gives you no time to relax and enjoy yourself. Get out of work mode and kick back. Don't feel as if every day needs an itinerary -- unless you're on a group tour and all you have to do is show up. Try to space out planned activities to every other day with alternate days off for whatever you feel like doing in the moment. You don't want to be exhausted from your vacation when it's all over.

5. Leave work behind.

The whole point of vacation is to take a break from work, not to have thoughts and messages from work mixing in with your thirst-quenching Mai Tai on the beach or your daring sky diving lesson. Leave the laptop behind, don't check voicemail, and don't call the office. Change your outgoing phone messages and set up an auto reply on email to make sure everyone knows you're not available until your return date. This is your time to put yourself first, renew your spirit and have a blissful experience!

For more by Debbie Gisonni, click here.

For more on emotional wellness, click here.

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Follow Debbie Gisonni on Twitter: www.twitter.com/debbiegisonni

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Source: http://www.huffingtonpost.com/debbie-gisonni/stress-vacation_b_3412571.html

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The Worst Nightmare For Gold Bugs Only Got Started? | Gold Silver ...

This article is as a guest post by Amanita Forecasting Service, which is amongst the top market timers around the world by ?Timer Digest.? It?contains a message that is not in line with the expectations of most gold bulls (the people behind Gold Silver Worlds included). Yet, there could be a significant truth in there. Besides, it puts the growing disconnect between the gold price and the monetary value of PHYSICAL gold in a relevant context. The article is in line with the latest trend we have reported, i.e. deflation. Amanita analyzes several solutions on how to handle the downside risk of the gold price but still benefit from the protective benefits of physical gold?(for paid subscribers only). Source: www.amanita.at

Already 6 months ago the premium subscribers of Amanita Market Forecasting were warned of gold. Also, the December 4, 2012 free Amanita newsletter (written in late November with gold near $1,750) already redflagged gold, by quoting: ?The gold bugs don?t like to hear that but without doubt the precious metals are an ugly investment *today*?? I made this statement with ? or in spite of? ? my background of being perhaps the only forecaster who called the beginning of the gold market. In 2000 a multi-year bull market was projected to begin either in early April or May 2001 ? as a matter of fact, it?started on April 2, 2001.

In December 2012 this super-bearish gold call was corroborated in several interviews with European print media (see here).

On January 29, 2013 with gold trading just short of $1,700 I wrote in the protected premium area (2-5 updates a month on average): ?While my assessment for the precious metals sector has deteriorated a lot the past?months, my outlook now suggests the ultimate nightmare. [?] the ?trapdoor to hell? is open & $500-$1,000 is not just realistic but likely. [?] Maybe I am now one of the biggest gold bears on the planet, which is a huge caesura.? This?unprecedented warning was issued just in time, as the plunge started in February?

Since mid-2012 we had exactly 2 tactical LONG signals: the first was exited on the day of the bull market high 10/5/12 (all-time high in euro terms), the other at the retest high before the crash.

The Amanita gold signals beat buy-and-hold by 14.0% in 2012, which was enough to be ranked #2 by the rating agency ?Timer Digest? which monitors the leading market timers around the globe.

For many years I have stressed the paramount importance of the August 2013 timeline. This starts the 40 quarters of testing & purification of mankind until the summer of 2023: end times in the narrow sense of the word (in a wider sense the end times already started in 1972). Since 2012 the late March 2013 timeline has been discussed as a precursor for August 2013. The Cyprus bank robbery by the illuminati in late March indeed turned over a new leaf: for the first time since WW2 the industrial states have engaged in direct dispossession, instead of indirect confiscation through fiat money inflation. Another effect of this timeline was the coldest March (actually the entire beginning of the year) in large parts of Europe since records began.

What is the impact of the end times on the financial markets? They will change more in the coming years than in the past 60+ years in total. That?s why the time needed to participate in the financial markets will explode: while in the past 60+ years maybe 2- 3 hours were enough for hobby speculations, be prepared for a half-time employment in the future! That?s why everyone not being a financial professional should make a big decision in 2013: either go fully into the markets ? or say good-bye to them altogether. I like the ship metaphor to demonstrate that: with fine weather (= the past 60+ years, in spite of dark clouds since 2008) you can set sail with a cockleshell, but when the sea is heavy (= the coming 10 years) you can?t go without the best ship & best crew you can find.

The coming decade marks the biggest investment plight in 5,000 years. From 2013 on you only have the ?choice? between bad, ugly & preposterously ugly investments. Satisfying or even good investment choices will no longer exist, let alone a ?safe haven?. That?s why from August 2013 on you should only trade the best financial instruments, especially futures & FOREX. Holders of retail instruments (warrants, but also ETFs/ ETNs, certificates) could face a total loss, as already in 2008 with securities issued by Lehman.

Source: http://goldsilverworlds.com/investing/the-worse-nightmare-for-gold-bugs-only-got-started/

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